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No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.These mice are homozygous for four different induced mutations."PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives."SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS.To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project."MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON").A functional microsomal triglyceride transfer protein gene (Mttp) is essential for establishing a hypercholesterolemic condition.By flanking the Mttp gene with lox P sites and including a Mx1-Cre transgene, it is possible to reduce total plasma cholesterol levels from 300 mg/dl to 30 mg/dl upon induction of the Cre recombinase by administering interferon alpha, interferon beta, or synthetic double-stranded RNA.

The vector was electroporated into 129S7/Sv Ev Brd-derived AB1 embryonic stem (ES) cells. Insertion of a neomycin resistance cassette into exon 4.

If we fail to produce animals of the correct genotype, you will not be charged.

We cannot guarantee the reproductive success of mice shipped to your facility.

Animals are typically ready to ship in 11-14 weeks.

If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks.

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